Neuroprotection for Retinal Ganglion Cells

Transpupillary thermotherapy: new observations on neuroprotection of retinal ganglion cells.

ranspupillary thermotherapy (TTT) is a technique in which heat s delivered to the posterior segment of the eye through the pupil sing a modified low power diode laser with a broad beam. This ethod uses infrared radiation to increase the temperature in the reated tissue up to 10 ◦C above baseline levels and it is been tried or the treatment of various intraocular tumors and choroidal neoasculari...

Inhibition of BDNF-AS Provides Neuroprotection for Retinal Ganglion Cells against Ischemic Injury

BACKGROUND Brain-derived neurotrophic factor (BDNF) protects retinal ganglion cells against ischemia in ocular degenerative diseases. We aimed to determine the effect of BDNF-AS on the ischemic injury of retinal ganglion cells. METHODS The levels of BDNF and BDNF-AS were measured in retinal ganglion cells subjected to oxygen and glucose deprivation. The lentiviral vectors were constructed to ...

Retinal Ganglion Cells

Segments from adult fish and rat retinae were explanted on myelinmarker expressing oligodendrocytes derived from the regenerating goldfish optic nerve. Fish axons grew in high density and even rat retinal axons regenerated to considerable length on the surface of the fish oligodendrocytes, suggesting that this type of fish glia has axon-growth promoting surface components that exert their influ...

Retinal Ganglion Cells

Taurine Provides Neuroprotection against Retinal Ganglion Cell Degeneration

Retinal ganglion cell (RGC) degeneration occurs in numerous retinal diseases leading to blindness, either as a primary process like in glaucoma, or secondary to photoreceptor loss. However, no commercial drug is yet directly targeting RGCs for their neuroprotection. In the 70s, taurine, a small sulfonic acid provided by nutrition, was found to be essential for the survival of photoreceptors, bu...